Basic Information
| Drug ID | DDPD08875 |
|
| Drug Name | Cabozantinib | |
| Molecular Weight | 501.514 | |
| Molecular Formula | C28H24FN3O5 | |
| CAS Number | 849217-68-1 | |
| SMILES | COC1=CC2=C(C=C1OC)C(OC1=CC=C(NC(=O)C3(CC3)C(=O)NC3=CC=C(F)C=C3)C=C1)=CC=N2 | |
| External Links | ||
| DRUGBANK | DB08875 | |
| PubChem Compound | 25102847 | |
| PDR | 3070 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 3.5 | h | 2-5 | h | PO, oral; | DRUGBANK |
| Clearance | 4.4 | L/h | 4.4 | L/h | at steady state; | DRUGBANK |
| Volume of Distribution | 349.0 | L | 349.0 | L | DRUGBANK | |
| Half-life | 55.0 | h | 55 | h | DRUGBANK | |
| Eliminate Route | 54.0 | % | 54 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 27.0 | % | 27 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 99.7 | % | >99.7 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 140.0 | mg/day | 140 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for adults | 180.0 | mg/day | 180 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for adults | 60.0 | mg/day | 60 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for adults | 80.0 | mg/day | 80 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for geriatric | 140.0 | mg/day | 140 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for geriatric | 180.0 | mg/day | 180 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for geriatric | 60.0 | mg/day | 60 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for geriatric | 80.0 | mg/day | 80 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Cometriq | cabozantinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1