Basic Information

Drug ID DDPD08865 ...
Drug Name Crizotinib
Molecular Weight 450.337
Molecular Formula C21H22Cl2FN5O
CAS Number 877399-52-5
SMILES [H][C@](C)(OC1=CC(=CN=C1N)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl
External Links
DRUGBANK DB08865
PubChem Compound 11626560
PDR 472
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.83 - 1.83 - MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 43.0 % 43 % Oral single dose; DRUGBANK
T Max 5.0 h 4-6 h Oral single dose; DRUGBANK
Tss 360.0 h 15 day PO, oral; DRUGBANK
Clearance 0.59 L/h/kg 9.75 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1772.0 L 1772.0 L Average volume of distribution; intravenous injection, IV; DRUGBANK
Volume of Distribution 22.2 L/kg 22.15 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 42.0 h 42 h terminal half-life; patients; DRUGBANK
Half-life 38.9 h 38.9 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 63.0 % 63 % Faeces excretion; Single dose; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 22.0 % 22 % Urinary excretion; Single dose; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 53.0 % 53 % Faeces excretion; Unchanged drug; DRUGBANK
Eliminate Route 2.3 % 2.3 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 91.0 % 91 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 500.0 mg/day 500 mg/day PO, oral Xalkori crizotinib PDR
Max dose for geriatric 500.0 mg/day 500 mg/day PO, oral Xalkori crizotinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1