Basic Information
| Drug ID | DDPD08860 |
|
| Drug Name | Pitavastatin | |
| Molecular Weight | 421.4608 | |
| Molecular Formula | C25H24FNO4 | |
| CAS Number | 147511-69-1 | |
| SMILES | O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC(O)=O | |
| External Links | ||
| DRUGBANK | DB08860 | |
| PubChem Compound | 5282452 | |
| PDR | 286 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 51.0 | % | 51 | % | PO, oral; | DRUGBANK |
| T Max | 1.0 | h | 1 | h | PO, oral; | DRUGBANK |
| Clearance | 43.4 | L/h | 43.4 | L/h | apparent clearance; Oral single dose; | DRUGBANK | Clearance | 0.35 | L/h/kg | 5.85 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 148.0 | L | 148.0 | L | DRUGBANK | Volume of Distribution | 0.90 | L/kg | 0.9 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 12.0 | h | ~12 | h | elimination half-life; | DRUGBANK | Half-life | 4.6 | h | 4.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 15.0 | % | 15 | % | Urinary excretion; Oral single dose; | DRUGBANK | Eliminate Route | 79.0 | % | 79 | % | Faeces excretion; Oral single dose; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 4.0 | mg/day | 4 | mg/day | PO, oral | Livalo | pitavastatin | PDR |
| Max dose for adolescents | 4.0 | mg/day | 4 | mg/day | PO, oral | Livalo | pitavastatin | PDR |
| Max dose for adults | 4.0 | mg/day | 4 | mg/day | PO, oral | Livalo | pitavastatin | PDR |
| Max dose for geriatric | 4.0 | mg/day | 4 | mg/day | PO, oral | Livalo | pitavastatin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1