Basic Information
| Drug ID | DDPD08827 |
|
| Drug Name | Lomitapide | |
| Molecular Weight | 693.7204 | |
| Molecular Formula | C39H37F6N3O2 | |
| CAS Number | 182431-12-5 | |
| SMILES | FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C2=C(C=CC=C2)C2=CC=C(C=C2)C(F)(F)F)C2=CC=CC=C2C2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB08827 | |
| PubChem Compound | 9853053 | |
| PDR | 3040 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 7.0 | % | 7 | % | Oral single dose; | DRUGBANK |
| T Max | 6.0 | h | 6 | h | Oral single dose; | DRUGBANK |
| Clearance | 0.52 | L/h/kg | 8.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1138.5 | L | 985-1292 | L | Steady state volume of distribution; | DRUGBANK | Volume of Distribution | 16.3 | L/kg | 16.3 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 39.7 | h | ~39.7 | h | DRUGBANK | Half-life | 39.7 | h | 39.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 56.2 | % | ~52.9-59.5 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 34.3 | % | ~33.4-35.1 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 99.8 | % | ~99.8 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 60.0 | mg/day | 60 | mg/day | PO, oral | Juxtapid | lomitapide | PDR |
| Max dose for geriatric | 60.0 | mg/day | 60 | mg/day | PO, oral | Juxtapid | lomitapide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1