Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD08816 ...
Drug Name Ticagrelor
Molecular Weight 522.568
Molecular Formula C23H28F2N6O4S
CAS Number 274693-27-5
SMILES CCCSC1=NC2=C(N=NN2[C@@H]2C[C@H](OCCO)[C@@H](O)[C@H]2O)C(N[C@@H]2C[C@H]2C2=CC(F)=C(F)C=C2)=N1
External Links
DRUGBANK DB08816
PubChem Compound 9871419
PDR 64
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Water Solubility 10.0 mg/L 10 μg/ml FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 6675.0 ng.h/ml 6675.0 ng.h/ml Oral single dose; DRUGBANK
AUC 2538.0 ng.h/ml 2538.0 ng.h/ml Oral single dose; Active metabolite; DRUGBANK
Bioavailability 36.0 % 36 % PO, oral; DRUGBANK
C Max 923.0 ng/ml 923 ng/ml Oral single dose; DRUGBANK
C Max 264.0 ng/ml 264 ng/ml Oral single dose; Active metabolite; DRUGBANK
T Max 1.5 h 1.5 h Oral single dose; DRUGBANK
T Max 3.0 h 3.0 h Oral single dose; Active metabolite; DRUGBANK
Clearance 0.005840 L/h 0.00584 L/h Renal clearance; DRUGBANK
Clearance 0.20 L/h/kg 3.38 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 88.0 L 88.0 L Steady state volume of distribution; DRUGBANK
Volume of Distribution 1.3 L/kg 1.25 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 8.0 h ~8 h elimination half-life; DRUGBANK
Half-life 12.0 h ~12 h elimination half-life; Active metabolite; DRUGBANK
Half-life 6.8 h 6.8 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 57.8 % 57.8 % Faeces excretion; DRUGBANK
Eliminate Route 26.5 % 26.5 % Urinary excretion; DRUGBANK
Protein Binding 99.0 % >99 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 180.0 mg/day 180 mg/day PO, oral Brilinta ticagrelor PDR
Max dose for geriatric 180.0 mg/day 180 mg/day PO, oral Brilinta ticagrelor PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1