Basic Information
| Drug ID | DDPD06823 |
|
| Drug Name | Tiopronin | |
| Molecular Weight | 163.19 | |
| Molecular Formula | C5H9NO3S | |
| CAS Number | 1953-02-2 | |
| SMILES | CC(S)C(=O)NCC(O)=O | |
| External Links | ||
| DRUGBANK | DB06823 | |
| PubChem Compound | 5483 | |
| PDR | 24363 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 63.0 | % | 63 | % | PO, oral; normal,healthy; | DRUGBANK |
| T Max | 4.5 | h | 3-6 | h | PO, oral; normal,healthy; | DRUGBANK |
| Metabolic | 12.5 | % | 10-15 | % | hydrolysis; | DRUGBANK |
| Clearance | 3.3 | L/h | 3.3 | L/h | Renal clearance; | DRUGBANK | Clearance | 13.3 | L/h | 13.3 | L/h | Renal clearance; | DRUGBANK | Clearance | 0.0888 | L/h/kg | 1.48 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 455.0 | L | 455.0 | L | DRUGBANK | Volume of Distribution | 1.4 | L/kg | 1.39 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 53.0 | h | 53 | h | terminal half-life; normal,healthy; | DRUGBANK | Half-life | 1.8 | h | 1.8 | h | DRUGBANK | Half-life | 55.0 | h | 55 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 100.0 | % | 100 | % | Urinary excretion; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 50.0 | mg/kg/day | 50 | mg/kg/day | PO, oral | Thiola EC | tiopronin | PDR |
| Max dose for adolescents | 50.0 | mg/kg/day | 50 | mg/kg/day | PO, oral | Thiola EC | tiopronin | PDR |
| Max dose for adults | 2000.0 | mg/day | 2000 | mg/day | PO, oral | Thiola EC | tiopronin | PDR |
| Max dose for adults | 3000.0 | mg/day | 3000 | mg/day | PO, oral | Thiola EC | tiopronin | PDR |
| Max dose for geriatric | 2000.0 | mg/day | 2000 | mg/day | PO, oral | Thiola EC | tiopronin | PDR |
| Max dose for geriatric | 3000.0 | mg/day | 3000 | mg/day | PO, oral | Thiola EC | tiopronin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1