Basic Information
| Drug ID | DDPD06788 |
|
| Drug Name | Histrelin | |
| Molecular Weight | 1443.632 | |
| Molecular Formula | C70H94N18O16 | |
| CAS Number | 76712-82-8 | |
| SMILES | CC(O)=O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1=CN(CC2=CC=CC=C2)C=N1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1 | |
| External Links | ||
| DRUGBANK | DB06788 | |
| PubChem Compound | 56927879 | |
| PDR | 2248 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 1.1 | ng/ml | 1.10±0.375 | ng/ml | subdermal implant; | DRUGBANK |
| T Max | 12.0 | h | 12 | h | subdermal implant; | DRUGBANK |
| Clearance | 10.4 | L/h | 174.0 | ml/min | Average clearance; metastatic prostate cancer; patients; | DRUGBANK |
| Volume of Distribution | 58.4 | L | 58.4±7.86 | L | Apparent volume of distribution; subcutaneous injection, SC; normal,healthy; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 1.0 | 1 | subdermal implant | Supprelin LA | histrelin acetate | PDR | ||
| Max dose for adolescents | 1.0 | 1 | subdermal implant | Supprelin LA | histrelin acetate | PDR | ||
| Max dose for adults | 1.0 | 1 | subdermal implant | Supprelin LA | histrelin acetate | PDR | ||
| Max dose for geriatric | 1.0 | 1 | subdermal implant | Supprelin LA | histrelin acetate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1