Basic Information
| Drug ID | DDPD06781 |
|
| Drug Name | Difluprednate | |
| Molecular Weight | 508.5515 | |
| Molecular Formula | C27H34F2O7 | |
| CAS Number | 23674-86-4 | |
| SMILES | [H][C@@]12CC[C@](OC(=O)CCC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C | |
| External Links | ||
| DRUGBANK | DB06781 | |
| PubChem Compound | 443936 | |
| PDR | 42 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 192.5 | ℃ | 191-194 | ℃ | Ercoli, A. and Gardi, R.; U.S. Patent 3,780,177; December 18,1973; assigned to Warner-Lambert Co. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Eliminate Route | 78.5 | % | 78.5 | % | Single dose; rabbit; | DRUGBANK | Eliminate Route | 99.5 | % | 99.5 | % | Single dose; rabbit; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Durezol | difluprednate | PDR |
| Max dose for children | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Durezol | difluprednate | PDR |
| Max dose for adolescents | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Durezol | difluprednate | PDR |
| Max dose for adults | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Durezol | difluprednate | PDR |
| Max dose for geriatric | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Durezol | difluprednate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1