Basic Information
| Drug ID | DDPD06774 |
|
| Drug Name | Capsaicin | |
| Molecular Weight | 305.4119 | |
| Molecular Formula | C18H27NO3 | |
| CAS Number | 404-86-4 | |
| SMILES | COC1=C(O)C=CC(CNC(=O)CCCC\C=C\C(C)C)=C1 | |
| External Links | ||
| DRUGBANK | DB06774 | |
| PubChem Compound | 1548943 | |
| PDR | 2160 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Boiling Point | 215.0 | ℃ | 210-220 | ℃ | MSDS |
| Melting Point | 65.0 | ℃ | 65 | ℃ | MSDS |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 70.0 | % | 50-90 | % | PO, oral; | DRUGBANK |
| C Max | 2.5 | ng/ml | 2.47±0.13 | ng/ml | PO, oral; | DRUGBANK | C Max | 1.9 | ng/ml | 1.86 | ng/ml | skin/dermal; | DRUGBANK |
| T Max | 1.0 | h | 1 | h | PO, oral; | DRUGBANK | T Max | 0.79 | h | 47.1±2.0 | min | PO, oral; | DRUGBANK |
| Half-life | 0.42 | h | ~24.9±5.0 | min | PO, oral; | DRUGBANK | Half-life | 24.0 | h | ~24 | h | skin/dermal; | DRUGBANK | Half-life | 1.6 | h | 1.64 | h | elimination half-life; Transdermal preparations; | DRUGBANK |
| Toxicity LD50 | 47.2 | mg/kg | 47.2 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 512.0 | mg/kg | >512 | mg/kg | skin/dermal; mouse; | DRUGBANK |
| Eliminate Route | 10.0 | % | <10 | % | Faeces excretion; animals; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 4.0 | application/day | 4 | application/day | skin/dermal | Qutenza | capsaicin | PDR |
| Max dose for children | 4.0 | application/day | 4 | application/day | skin/dermal | Qutenza | capsaicin | PDR |
| Max dose for children | 4.0 | application/day | 4 | application/day | skin/dermal | Qutenza | capsaicin | PDR |
| Max dose for adolescents | 4.0 | application/day | 4 | application/day | skin/dermal | Qutenza | capsaicin | PDR |
| Max dose for adults | 4.0 | patches/treatment | 4 | patches/treatment | Transdermal preparations | Qutenza | capsaicin | PDR |
| Max dose for adults | 4.0 | appLication/day | 4 | appLication/day | skin ointment;skin/dermal; | Qutenza | capsaicin | PDR |
| Max dose for adults | 5.0 | times/day | 5 | times/day | skin/dermal | Qutenza | capsaicin | PDR |
| Max dose for geriatric | 4.0 | patches/treatment | 4 | patches/treatment | Transdermal preparations | Qutenza | capsaicin | PDR |
| Max dose for geriatric | 4.0 | application/day | 4 | application/day | skin ointment;skin/dermal; | Qutenza | capsaicin | PDR |
| Max dose for geriatric | 5.0 | times/day | 5 | times/day | skin/dermal | Qutenza | capsaicin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1