Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06772 ...
Drug Name Cabazitaxel
Molecular Weight 835.9324
Molecular Formula C45H57NO14
CAS Number 183133-96-2
SMILES [H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C4=CC=CC=C4)C(C)=C([C@@H](OC)C(=O)[C@]1(C)[C@H](C[C@H]1OC[C@@]21OC(C)=O)OC)C3(C)C
External Links
DRUGBANK DB06772
PubChem Compound 9854073
PDR 518
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 991.0 ng.h/ml 991.0 ng.h/ml intravenous injection, IV; metastatic prostate cancer; DRUGBANK
C Max 226.0 ng/ml 226 ng/ml intravenous injection, IV; metastatic prostate cancer; DRUGBANK
T Max 1.0 h 1 h intravenous injection, IV; metastatic prostate cancer; DRUGBANK
Metabolic 95.0 % >95 % Liver metabolism; DRUGBANK
Clearance 48.5 L/h 48.5 L/h Plasma clearance; metastatic prostate cancer; DRUGBANK
Clearance 0.66 L/h/kg 11 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 4864.0 L 4864.0 L at steady state; DRUGBANK
Volume of Distribution 48.0 L/kg 48 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.0667 h 4 min distribution half-life; intravenous infusion, IV in drop; DRUGBANK
Half-life 2.0 h 2 h elimination half-life; intravenous infusion, IV in drop; DRUGBANK
Half-life 95.0 h 95 h terminal half-life; intravenous infusion, IV in drop; DRUGBANK
Half-life 74.5 h 74.5 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 500.0 mg/kg 500.0 mg/kg Rattus, Rat; DRUGBANK
Eliminate Route 80.0 % ~80 % intravenous infusion, IV in drop; DRUGBANK
Protein Binding 82.0 % 82 % human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 25.0 mg/m2 25 mg/m2 intravenous injection, IV q3w Jevtana cabazitaxel PDR
Max dose for elderly 25.0 mg/m2 25 mg/m2 intravenous injection, IV q3w Jevtana cabazitaxel PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1