Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06769 ...
Drug Name Bendamustine
Molecular Weight 358.263
Molecular Formula C16H21Cl2N3O2
CAS Number 16506-27-7
SMILES CN1C(CCCC(O)=O)=NC2=CC(=CC=C12)N(CCCl)CCCl
External Links
DRUGBANK DB06769
PubChem Compound 65628
PDR 2333

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 42.0 L/h 700.0 ml/min DRUGBANK
Clearance 0.27 L/h/kg 4.49 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 22.5 L ~20-25 L DRUGBANK
Volume of Distribution 0.22 L/kg 0.22 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.67 h 40 min DRUGBANK
Half-life 0.41 h 0.41 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 50.0 % ~50 % Urinary excretion; intravenous infusion, IV in drop; tumor; DRUGBANK
Eliminate Route 25.0 % ~25 % Faeces excretion; intravenous infusion, IV in drop; tumor; DRUGBANK
Protein Binding 95.0 % 94-96 % plasma proteins; high protein binding; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 100.0 mg/m2 100 mg/m2 Treanda bendamustine hydrochloride PDR
Max dose for adults 120.0 mg/m2 120 mg/m2 Treanda bendamustine hydrochloride PDR
Max dose for geriatric 100.0 mg/m2 100 mg/m2 Treanda bendamustine hydrochloride PDR
Max dose for geriatric 120.0 mg/m2 120 mg/m2 Treanda bendamustine hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1