Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06717 ...
Drug Name Fosaprepitant
Molecular Weight 614.4066
Molecular Formula C23H22F7N4O6P
CAS Number 172673-20-0
SMILES C[C@@H](O[C@H]1OCCN(CC2=NC(=O)N(N2)P(O)(O)=O)[C@H]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
External Links
DRUGBANK DB06717
PubChem Compound 219090
PDR 24381

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 1.1 L/h/kg 18.6 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.0700 L/kg 0.07 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 11.0 h 9-13 h DRUGBANK
Half-life 2.2 h 2.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 95.0 % >95 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 3.0 mg/kg/day 3 mg/kg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for infants 2.0 mg/kg/day 2 mg/kg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for infants 5.0 mg/kg/day 5 mg/kg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for infants 3.0 mg/kg/day 3 mg/kg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 125.0 mg/day 125 mg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 80.0 mg/day 80 mg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for children 150.0 mg/day 150 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 115.0 mg/day 115 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 3.0 mg/kg/day 3 mg/kg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 125.0 mg/day 125 mg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 2.0 mg/kg/day 2 mg/kg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for children 80.0 mg/day 80 mg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 150.0 mg/day 150 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 3.0 mg/kg/day 3 mg/kg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 115.0 mg/day 115 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 3.0 mg/kg/day 3 mg/kg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 125.0 mg/day 125 mg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 2.0 mg/kg/day 2 mg/kg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for children 80.0 mg/day 80 mg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for children 5.0 mg/kg/day 5 mg/kg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 150.0 mg/day 150 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 3.0 mg/kg/day 3 mg/kg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for children 115.0 mg/day 115 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for adolescents 125.0 mg/day 125 mg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for adolescents 80.0 mg/day 80 mg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for adolescents 150.0 mg/day 150 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for adolescents 115.0 mg/day 115 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for adults 125.0 mg/day 125 mg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for adults 80.0 mg/day 80 mg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for adults 150.0 mg/day 150 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for adults 130.0 mg/day 130 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for geriatric 125.0 mg/day 125 mg/day PO, oral; day1 Fosaprepitant fosaprepitant PDR
Max dose for geriatric 80.0 mg/day 80 mg/day PO, oral; day2 and day3 Fosaprepitant fosaprepitant PDR
Max dose for geriatric 150.0 mg/day 150 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR
Max dose for geriatric 130.0 mg/day 130 mg/day intravenous injection, IV; day1 Fosaprepitant fosaprepitant PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1