Basic Information
| Drug ID | DDPD06703 |
|
| Drug Name | Gadobutrol | |
| Molecular Weight | 604.72 | |
| Molecular Formula | C18H31GdN4O9 | |
| CAS Number | 770691-21-9 | |
| SMILES | OC[C@H](O)[C@H](CO)[N+]12CC[N+]3(CC([O-])=O)CC[N+]4(CC([O-])=O)CC[N+](CC([O-])=O)(CC1)[Gd-]234 | |
| External Links | ||
| DRUGBANK | DB06703 | |
| PubChem Compound | 70678987 | |
| PDR | 3521 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 665192.0 | ng.h/ml | 1.1±0.1 | mmol.h/L | normal renal function; | DRUGBANK |
| Metabolic | 0 | % | 0 | % | DRUGBANK | |
| Clearance | 0.0840 | L/h/kg | 1.1-1.7 | ml/min/kg | Renal clearance; normal,healthy; | DRUGBANK | Clearance | 0.12 | L/h/kg | 0.1-0.13 | L/h/kg | Average clearance; Children; | DRUGBANK | Clearance | 0.0900 | L/h/kg | 0.09 | L/h/kg | Average clearance; Adolescents; | DRUGBANK | Clearance | 0.12 | L/h/kg | 2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.22 | L/kg | 0.22 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.8 | h | 1.81(1.33-2.13) | h | DRUGBANK | Half-life | 1.3 | h | 1.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.1 | ml/kg/dose | 0.1 | ml/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for neonates | 0.1 | mmol/kg/dose | 0.1 | mmol/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for infants | 0.1 | ml/kg/dose | 0.1 | ml/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for infants | 0.1 | mmoL/kg/dose | 0.1 | mmoL/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for children | 0.1 | ml/kg/dose | 0.1 | ml/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for children | 0.1 | mmol/kg/dose | 0.1 | mmol/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for adolescents | 0.1 | ml/kg/dose | 0.1 | mL/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for adolescents | 0.1 | mmol/kg/dose | 0.1 | mmol/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for adults | 0.1 | ml/kg/dose | 0.1 | ml/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for adults | 0.1 | mmoL/kg/dose | 0.1 | mmoL/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for geriatric | 0.1 | ml/kg/dose | 0.1 | ml/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
| Max dose for geriatric | 0.1 | mmol/kg/dose | 0.1 | mmol/kg/dose | intravenous injection, IV | Gadavist | gadobutrol | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1