Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06701 ...
Drug Name Dexmethylphenidate
Molecular Weight 233.3062
Molecular Formula C14H19NO2
CAS Number 40431-64-9
SMILES [H][C@@](C(=O)OC)(C1=CC=CC=C1)[C@@]1([H])CCCCN1
External Links
DRUGBANK DB06701
T3DB T3D4563
PubChem Compound 154101
PDR 431

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 203.0 ℃ >203 ℃ [MSDS]

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 90.0 % 90 % PO, oral; DRUGBANK
Bioavailability 23.0 % 23 % PO, oral; DRUGBANK
Bioavailability 5.0 % 5 % PO, oral; Raceme L; DRUGBANK
T Max 1.3 h 1-1.5 h PO, oral; Raceme L; DRUGBANK
Clearance 0.40 L/h/kg 0.4 l/h/kg intravenous injection, IV; DRUGBANK
Clearance 0.005000 L/h/kg 0.005 l/h/kg Renal clearance; DRUGBANK
Clearance 0.40 L/h/kg 6.67 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.7 L/kg 2.65 L/kg intravenous injection, IV; DRUGBANK
Volume of Distribution 2.7 L/kg 2.65 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.2 h ~2.2 h terminal half-life; DRUGBANK
Half-life 3.9 h 3.8-3.9 h different study; DRUGBANK
Half-life 6.0 h 5.96 h intravenous injection, IV; DRUGBANK
Half-life 5.7 h 5.69 h PO, oral; DRUGBANK
Half-life 8.0 h 8 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 190.0 mg/kg 190.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 90.0 % 90 % Urinary excretion; DRUGBANK
Eliminate Route 3.3 % 3.3 % Faeces excretion; DRUGBANK
Protein Binding 13.5 % 12-15 % DRUGBANK
Protein Binding 15.2 % 15.2±5.2 % Children; DRUGBANK
Protein Binding 16.2 % 16.2±1.1 % adults; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 20.0 mg/day 20 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for children 30.0 mg/day 30 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for children 50.0 mg/day 50 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for adolescents 20.0 mg/day 20 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for adolescents 30.0 mg/day 30 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for adolescents 50.0 mg/day 50 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for adults 20.0 mg/day 20 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for geriatric 20.0 mg/day 20 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Focalin XR dexmethylphenidate hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1