Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06699 ...
Drug Name Degarelix
Molecular Weight 1632.29
Molecular Formula C82H103ClN18O16
CAS Number 214766-78-6
SMILES CC(C)C[C@H](NC(=O)[C@@H](CC1=CC=C(NC(N)=O)C=C1)NC(=O)[C@H](CC1=CC=C(NC(=O)[C@@H]2CC(=O)NC(=O)N2)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CC=CN=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC=C2C=CC=CC2=C1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
External Links
DRUGBANK DB06699
PubChem Compound 16136245
PDR 1311
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 330.0 ng/ml 330 ng/ml subcutaneous injection, SC; DRUGBANK
T Max 6.0 h 6 h subcutaneous injection, SC; DRUGBANK
Clearance 9.0 L/h ~9 L/h subcutaneous injection, SC; metastatic prostate cancer; DRUGBANK
Clearance 0.0408 L/h/kg 0.68 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 10.1 L 8.88-11.4 L Total volume of distribution; DRUGBANK
Volume of Distribution 40.9 L 40.9 L Total volume of distribution; DRUGBANK
Volume of Distribution 0.74 L/kg 0.74 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1340.4 h 41.5-70.2 day terminal half-life; DRUGBANK
Half-life 32.9 h 32.9 h distribution half-life; DRUGBANK
Half-life 28.1 h 1.17 day DRUGBANK
Half-life 18.6 h 18.6 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 75.0 % 70-80 % Faeces excretion; DRUGBANK
Eliminate Route 25.0 % 20-30 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 90.0 % 90 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 240.0 mg 240 mg subcutaneous injection, SC Firmagon degarelix PDR
Max dose for geriatric 240.0 mg 240 mg subcutaneous injection, SC Firmagon degarelix PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1