Basic Information
| Drug ID | DDPD06695 |
|
| Drug Name | Dabigatran etexilate | |
| Molecular Weight | 627.7332 | |
| Molecular Formula | C34H41N7O5 | |
| CAS Number | 211915-06-9 | |
| SMILES | CCCCCCOC(=O)\N=C(\N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C3=NC=CC=C3)N2C)C=C1 | |
| External Links | ||
| DRUGBANK | DB06695 | |
| PubChem Compound | 6445226 | |
| PDR | 100 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.8 | - | 3.8 | - | Apotex Inc. Product Monograph: Dabigatran Etexilate |
| Melting Point | 132.0 | ℃ | 132 | ℃ | http://www.chemspider.com/Chemical-Structure.8615298.html |
| Water Solubility | 1800.0 | mg/L | 1.8 | mg/ml | MSDS |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 5.0 | % | 3-7 | % | PO, oral; fasting; | DRUGBANK |
| T Max | 1.0 | h | 1 | h | PO, oral; fasting; | DRUGBANK | T Max | 2.0 | h | 2 | h | PO, oral; high-fat meal; | DRUGBANK |
| Volume of Distribution | 60.0 | L | 50-70 | L | DRUGBANK | |
| Half-life | 14.5 | h | 12-17 | h | DRUGBANK | |
| Eliminate Route | 7.0 | % | 7 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 86.0 | % | 86 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 35.0 | % | ~35 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Pradaxa | dabigatran etexilate mesylate | PDR |
| Max dose for elderly | 300.0 | mg/day | 300 | mg/day | PO, oral | Pradaxa | dabigatran etexilate mesylate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1