Basic Information
| Drug ID | DDPD06663 |
|
| Drug Name | Pasireotide | |
| Molecular Weight | 1047.2062 | |
| Molecular Formula | C58H66N10O9 | |
| CAS Number | 396091-73-9 | |
| SMILES | NCCCC[C@@H]1NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(OCC3=CC=CC=C3)C=C2)NC1=O)OC(=O)NCCN)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB06663 | |
| PubChem Compound | 9941444 | |
| PDR | 3098 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 0.38 | h | 0.25-0.5 | h | DRUGBANK | |
| Clearance | 7.6 | L/h | ~7.6 | L/h | normal,healthy; patients; | DRUGBANK | Clearance | 3.8 | L/h | ~3.8 | L/h | Cushing's Disease; patients; | DRUGBANK |
| Volume of Distribution | 100.0 | L | >100 | L | DRUGBANK | |
| Half-life | 12.0 | h | 12 | h | DRUGBANK | |
| Eliminate Route | 48.0 | % | ~48 | % | Bile excretion; | DRUGBANK | Eliminate Route | 7.6 | % | ~7.63 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 88.0 | % | 88 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1.8 | mg/day | 1.8 | mg/day | subcutaneous injection, SC | Signifor | pasireotide | PDR |
| Max dose for adults | 40.0 | mg | 40 | mg | IM,intramuscular injection | Signifor | pasireotide | PDR |
| Max dose for adults | 60.0 | mg | 60 | mg | IM,intramuscular injection | Signifor | pasireotide | PDR |
| Max dose for geriatric | 1.8 | mg/day | 1.8 | mg/day | subcutaneous injection, SC | Signifor | pasireotide | PDR |
| Max dose for geriatric | 40.0 | mg | 40 | mg | IM,intramuscular injection | Signifor | pasireotide | PDR |
| Max dose for geriatric | 60.0 | mg | 60 | mg | IM,intramuscular injection | Signifor | pasireotide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1