Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06654 ...
Drug Name Safinamide
Molecular Weight 302.349
Molecular Formula C17H19FN2O2
CAS Number 133865-89-1
SMILES C[C@H](NCC1=CC=C(OCC2=CC(F)=CC=C2)C=C1)C(N)=O
External Links
DRUGBANK DB06654
PubChem Compound 131682
PDR 24081

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 95.0 % 95 % DRUGBANK
T Max 3.0 h 2-4 h DRUGBANK
Clearance 0.0175 L/h/kg 17.53±2.71 ml/h/kg Plasma clearance; PO, oral; DRUGBANK
Clearance 0.0702 L/h/kg 1.17 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.8 L/kg 1.8 L/kg DRUGBANK
Volume of Distribution 2.2 L/kg 2.19 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 22.0 h 22 h DRUGBANK
Half-life 21.7 h 21.67 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 76.0 % 76 % Urinary excretion; DRUGBANK
Eliminate Route 1.5 % 1.5 % Faeces excretion; DRUGBANK
Protein Binding 89.0 % 88-90 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 100.0 mg/day 100 mg/day PO, oral Xadago safinamide PDR
Max dose for geriatric 100.0 mg/day 100 mg/day PO, oral Xadago safinamide PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1