| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Reference |
| Absorption |
100.0 |
% |
100 |
% |
PO, oral; |
DRUGBANK |
| C Max |
19.5 |
ng/ml |
17.3-21.6 |
ng/ml |
PO, oral; extended release formulation; |
DRUGBANK |
| T Max |
1.0 |
h |
1 |
h |
PO, oral; immediate release formulation; |
DRUGBANK |
T Max |
3.5 |
h |
3.5 |
h |
PO, oral; extended release formulation; |
DRUGBANK |
| Clearance |
0.56 |
L/h/kg |
9.3 |
ml/min/kg |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution |
2.6 |
L/kg |
2.6 |
L/kg |
|
DRUGBANK |
Volume of Distribution |
2.6 |
L/kg |
2.6 |
L/kg |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Half-life |
3.5 |
h |
3.5 |
h |
distribution half-life; |
DRUGBANK |
Half-life |
5.5 |
h |
5.47 |
h |
elimination half-life; |
DRUGBANK |
Half-life |
3.6 |
h |
3.6 |
h |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 |
19.0 |
mg/kg |
19.0 |
mg/kg |
PO, oral; mouse; |
DRUGBANK |
Toxicity LD50 |
21.0 |
mg/kg |
21.0 |
mg/kg |
PO, oral; Rattus, Rat; |
DRUGBANK |
Toxicity LD50 |
19.0 |
mg/kg |
19.0 |
mg/kg |
PO, oral; mouse; |
T3DB |
Toxicity LD50 |
21.0 |
mg/kg |
21.0 |
mg/kg |
PO, oral; Rattus, Rat; |
T3DB |
Toxicity LD50 |
24.5 |
mg/kg |
20-29 |
mg/kg |
PO, oral; Rattus, Rat; |
T3DB |
Toxicity LD50 |
3.7 |
mg/kg |
3.7 |
mg/kg |
PO, oral; dog; |
T3DB |
Toxicity LD50 |
326.0 |
mg/kg |
326.0 |
mg/kg |
skin/dermal; rabbit; |
T3DB |
| Eliminate Route |
96.0 |
% |
96 |
% |
Urinary excretion; |
DRUGBANK |
Eliminate Route |
0.50 |
% |
0.5 |
% |
Faeces excretion; |
DRUGBANK |
Eliminate Route |
90.0 |
% |
90 |
% |
Urinary excretion; Unchanged drug; |
DRUGBANK |
| Protein Binding |
2.0 |
% |
1-3 |
% |
extended release formulation; |
DRUGBANK |
