Basic Information
| Drug ID | DDPD06636 |
|
| Drug Name | Isavuconazonium | |
| Molecular Weight | 717.77 | |
| Molecular Formula | C35H35F2N8O5S | |
| CAS Number | 742049-41-8 | |
| SMILES | [H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1 | |
| External Links | ||
| DRUGBANK | DB06636 | |
| PubChem Compound | 6918606 | |
| PDR | 3711 | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 98.0 | % | 98 | % | PO, oral; | DRUGBANK |
| Volume of Distribution | 450.0 | L | 450.0 | L | DRUGBANK | |
| Half-life | 105.0 | h | 80-130 | h | DRUGBANK | |
| Eliminate Route | 45.0 | % | 45 | % | Faeces excretion; Bile excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1116.0 | mg/day | 1116 | mg/day | PO, oral;intravenous injection, IV; | Cresemba | isavuconazonium sulfate | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral;intravenous injection, IV; | Cresemba | isavuconazonium sulfate | PDR |
| Max dose for geriatric | 1116.0 | mg/day | 1116 | mg/day | PO, oral;intravenous injection, IV; | Cresemba | isavuconazonium sulfate | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral;intravenous injection, IV; | Cresemba | isavuconazonium sulfate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1