Basic Information
| Drug ID | DDPD06626 |
|
| Drug Name | Axitinib | |
| Molecular Weight | 386.47 | |
| Molecular Formula | C22H18N4OS | |
| CAS Number | 319460-85-0 | |
| SMILES | CNC(=O)C1=C(SC2=CC=C3C(NN=C3\C=C\C3=CC=CC=N3)=C2)C=CC=C1 | |
| External Links | ||
| DRUGBANK | DB06626 | |
| PubChem Compound | 6450551 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Water Solubility | 0.2 | mg/L | 0.2 | ug/ml | From FDA label. |
| pKa | 4.8 | - | 4.8 | - | From FDA label. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 3.3 | h | 2.5-4.1 | h | DRUGBANK | |
| Clearance | 38.0 | L/h | 38.0 | L/h | Average clearance; | DRUGBANK | Clearance | 0.30 | L/h/kg | 5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 160.0 | L | 160.0 | L | DRUGBANK | |
| Half-life | 4.3 | h | 2.5-6.1 | h | DRUGBANK | Half-life | 4.3 | h | 4.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 23.0 | % | 23 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 12.0 | % | 12 | % | Unchanged drug; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1