DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD06616
Drug Name	Bosutinib
Molecular Weight	530.446
Molecular Formula	C26H29Cl2N5O3
CAS Number	380843-75-4
SMILES	COC1=CC(NC2=C(C=NC3=CC(OCCCN4CCN(C)CC4)=C(OC)C=C23)C#N)=C(Cl)C=C1Cl
External Links
	DRUGBANK	DB06616
	PubChem Compound	5328940
	PDR	2592
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	3650.0	ng.h/ml	3650.0	ng.h/ml	PO, oral; Chronic myelogenous leukemia; food;		DRUGBANK
C Max	200.0	ng/ml	200	ng/ml	PO, oral; Chronic myelogenous leukemia; food;		DRUGBANK
T Max	5.0	h	4-6	h	Oral single dose; tumor; food;		DRUGBANK
Clearance	189.0	L/h	189.0	L/h	Average clearance; Oral single dose; food;		DRUGBANK
Volume of Distribution	6080.0	L	6080 ± 1230	L	Apparent volume of distribution;		DRUGBANK
Half-life	22.5	h	22.5	h	elimination half-life; Oral single dose;		DRUGBANK
Eliminate Route	91.3	%	91.3	%	Faeces excretion; Oral single dose;		DRUGBANK
Eliminate Route	3.0	%	3	%	Urinary excretion; Oral single dose;		DRUGBANK
Protein Binding	94.0	%	94	%	plasma proteins; high protein binding;	Plasma Concentration → ;	DRUGBANK
Protein Binding	96.0	%	96	%	plasma proteins; in vivo; normal,healthy; human, homo sapiens;		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	600.0	mg/day	600	mg/day	PO, oral	Bosulif	bosutinib	PDR
Max dose for geriatric	600.0	mg/day	600	mg/day	PO, oral	Bosulif	bosutinib	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1