Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06608 ...
Drug Name Tafenoquine
Molecular Weight 463.501
Molecular Formula C24H28F3N3O3
CAS Number 106635-80-7
SMILES COC1=CC(C)=C2C(OC3=CC=CC(=C3)C(F)(F)F)=C(OC)C=C(NC(C)CCCN)C2=N1
External Links
DRUGBANK DB06608
PDR 24286

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
pKa 9.5 - 9.5 - Marella A. et al. (2013). Saudi Pharm J. Jan; 21 (1): 1-12
Log S 2.04 - 2.04 - Marella A. et al. (2013). Saudi Pharm J. Jan; 21 (1): 1-12

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
T Max 13.8 h 13.8 h DRUGBANK
Clearance 6.0 L/h ~6 L/h DRUGBANK
Volume of Distribution 2560.0 L ~2560 L DRUGBANK
Half-life 336.0 h ~14 day DRUGBANK
Protein Binding 99.5 % ~99.5 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 300.0 mg/dose 300 mg/dose PO, oral Krintafel tafenoquine PDR
Max dose for adults 300.0 mg/dose 300 mg/dose PO, oral Krintafel tafenoquine PDR
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Krintafel tafenoquine PDR
Max dose for adults 28.5714285714286 mg/day 200 mg/week PO, oral Krintafel tafenoquine PDR
Max dose for geriatric 300.0 mg/dose 300 mg/dose PO, oral Krintafel tafenoquine PDR
Max dose for geriatric 200.0 mg/day 200 mg/day PO, oral Krintafel tafenoquine PDR
Max dose for geriatric 28.5714285714286 mg/day 200 mg/week PO, oral Krintafel tafenoquine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1