Basic Information
| Drug ID | DDPD06595 |
|
| Drug Name | Midostaurin | |
| Molecular Weight | 570.649 | |
| Molecular Formula | C35H30N4O4 | |
| CAS Number | 120685-11-2 | |
| SMILES | CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O)N(C)C(=O)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB06595 | |
| PubChem Compound | 9829523 | |
| PDR | 24073 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.89 | - | 5.89 | - | DRUGBANK |
| Melting Point | 247.5 | ℃ | 235-260 | ℃ | Alfa Aesar MSDS |
| Water Solubility | 1000.0 | mg/L | <1 | mg/ml | Abmole MSDS |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 2.0 | h | 1-3 | h | PO, oral; patients; fasting; | DRUGBANK |
| Clearance | 1.5 | L/h | 1.47 | L/h | DRUGBANK | Clearance | 0.50 | L/h | 0.501 | L/h | DRUGBANK |
| Volume of Distribution | 95.2 | L | 95.2 | L | DRUGBANK | |
| Half-life | 21.0 | h | ~21 | h | elimination half-life; | DRUGBANK | Half-life | 32.0 | h | 32 | h | elimination half-life; | DRUGBANK | Half-life | 482.0 | h | 482 | h | elimination half-life; | DRUGBANK |
| Toxicity LD50 | 300.0 | mg/kg | 300.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 980.0 | mg/kg | 980.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 3200.0 | mg/kg | 3200.0 | mg/kg | PO, oral; rabbit; | DRUGBANK |
| Eliminate Route | 95.0 | % | 95 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 5.0 | % | 5 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 3.8 | % | 3.8 | % | Faeces excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.8 | % | >99.8 | % | plasma proteins; high protein binding; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 100.0 | mg | 100 | mg | PO, oral | bid | Rydapt | midostaurin | PDR |
| Max dose for geriatric | 100.0 | mg | 100 | mg | PO, oral | bid | Rydapt | midostaurin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1