Basic Information
| Drug ID | DDPD06590 |
|
| Drug Name | Ceftaroline fosamil | |
| Molecular Weight | 684.67 | |
| Molecular Formula | C22H21N8O8PS4 | |
| CAS Number | 229016-73-3 | |
| SMILES | [H][C@]12SCC(SC3=NC(=CS3)C3=CC=[N+](C)C=C3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC)\C1=NSC(NP(O)(O)=O)=N1)C([O-])=O | |
| External Links | ||
| DRUGBANK | DB06590 | |
| PubChem Compound | 9852981 | |
| PDR | 158 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Water Solubility | 100000.0 | mg/L | >100 | mg/ml | # Steed ME, Rybak MJ: Ceftaroline: a new cephalosporin with activity against resistant gram-positive pathogens. Pharmacotherapy. 2010 Apr;304):375-89. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20334458 |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 5.0 | L/h/kg | 83.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 20.3 | L | 20.3 | L | Average volume of distribution; | DRUGBANK | Volume of Distribution | 0.53 | L/kg | 0.53 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.6 | h | 1.60 | h | DRUGBANK | Half-life | 0.0900 | h | 0.09 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 300.0 | mg/kg | 300.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 3200.0 | mg/kg | 3200.0 | mg/kg | PO, oral; rabbit; | DRUGBANK | Toxicity LD50 | 980.0 | mg/kg | 980.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 6.0 | % | 6 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 20.0 | % | ~20 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 18.0 | mg/kg/day | 18 | mg/kg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for infants | 24.0 | mg/kg/day | 24 | mg/kg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for infants | 18.0 | mg/kg/day | 18 | mg/kg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for children | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for children | 36.0 | mg/kg/day | 36 | mg/kg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for children | 24.0 | mg/kg/day | 24 | mg/kg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for adolescents | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for adolescents | 36.0 | mg/kg/day | 36 | mg/kg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for adults | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
| Max dose for geriatric | 1200.0 | mg/day | 1200 | mg/day | intravenous injection, IV | Teflaro | ceftaroline fosamil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1