DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD06589
Drug Name	Pazopanib
Molecular Weight	437.518
Molecular Formula	C21H23N7O2S
CAS Number	444731-52-6
SMILES	CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=CC=NC(NC2=CC=C(C)C(=C2)S(N)(=O)=O)=N1
External Links
	DRUGBANK	DB06589
	PubChem Compound	10113978
	PDR	236
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
AUC	1037000.0	ng.h/ml	1037.0	ug.h/ml	PO, oral;	DRUGBANK
Bioavailability	21.0	%	21	%	PO, oral; tumor;	DRUGBANK
C Max	58100.0	ng/ml	58.1	ug/ml	PO, oral;	DRUGBANK
Clearance	0.24	L/h	4.0	ml/min	intravenous injection, IV; tumor; patients;	DRUGBANK
Clearance	0.003600	L/h/kg	0.06	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	11.1	L	11.1	L	Steady state volume of distribution; intravenous injection, IV; tumor; patients;	DRUGBANK
Volume of Distribution	0.16	L/kg	0.16	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	35.0	h	35	h		DRUGBANK
Eliminate Route	82.2	%	82.2	%	Faeces excretion; tumor;	DRUGBANK
Eliminate Route	4.0	%	<4	%	Urinary excretion; tumor;	DRUGBANK
Protein Binding	99.0	%	>99	%		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	800.0	mg/day	800	mg/day	PO, oral	Votrient	pazopanib	PDR
Max dose for elderly	800.0	mg/day	800	mg/day	PO, oral	Votrient	pazopanib	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1