Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.56 | - | 2.56 | - | 'MSDS' |
| Melting Point | 196.0 | ℃ | >196 | ℃ | 'MSDS' |
| Water Solubility | 1000.0 | mg/L | <1 | mg/ml | 'MSDS' |
| pKa | 8.5 | - | 8.5 | - | Resotrans data sheet (measure of piperidine moiety) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| AUC | 96.5 | mn.h/ml | 96.5 | mn.h/ml | DRUGBANK | ||
| Bioavailability | 90.0 | % | >90 | % | PO, oral; food; | food → ; | DRUGBANK |
| C Max | 3.8 | ng/ml | 3.79 | ng/ml | DRUGBANK | ||
| T Max | 2.8 | h | 2.77 | h | DRUGBANK | ||
| Metabolic | 6.0 | % | 6 | % | DRUGBANK | ||
| Clearance | 17.0 | L/h | 17.0 | L/h | Renal clearance; | DRUGBANK | Clearance | 0.27 | L/h/kg | 4.55 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 623.0 | L | 623.0 | L | Average volume of distribution; | DRUGBANK | Volume of Distribution | 8.7 | L/kg | 8.73 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 19.0 | h | ~18-20 | h | DRUGBANK | Half-life | 22.5 | h | 22.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 84.0 | % | 84 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 13.0 | % | 13 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 30.0 | % | 30 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1