Basic Information
| Drug ID | DDPD06282 |
|
| Drug Name | Levocetirizine | |
| Molecular Weight | 388.89 | |
| Molecular Formula | C21H25ClN2O3 | |
| CAS Number | 130018-77-8 | |
| SMILES | OC(=O)COCCN1CCN(CC1)[C@H](C1=CC=CC=C1)C1=CC=C(Cl)C=C1 | |
| External Links | ||
| DRUGBANK | DB06282 | |
| PubChem Compound | 1549000 | |
| PDR | 24038 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Boiling Point | 542.1 | ℃ | 542.1 | ℃ | http://www.chemspider.com/Chemical-Structure.1266001.html |
| Melting Point | 206.5 | ℃ | 205-208 | ℃ | http://www.chemspider.com/Chemical-Structure.1266001.html |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| AUC | 2310.0 | ng.h/ml | 2.31±0.50 | ug.h/ml | PO, oral; | DRUGBANK | |
| C Max | 27000.0 | ng/ml | 27±0.04 | ug/ml | PO, oral; | DRUGBANK | |
| T Max | 0.75 | h | 0.75±0.50 | h | PO, oral; | DRUGBANK | T Max | 2.0 | h | 2±0.50 | h | PO, oral; food; | food ↑ ; | DRUGBANK |
| Metabolic | 85.8 | % | 85.8 | % | Urinary excretion; Faeces excretion; Unchanged drug; | DRUGBANK | |
| Clearance | 0.0342 | L/h/kg | 0.57±0.18 | ml/min/kg | Average clearance; | DRUGBANK | |
| Volume of Distribution | 0.33 | L/kg | 0.33±0.02 | L/kg | DRUGBANK | ||
| Half-life | 7.1 | h | 7.05±1.54 | h | DRUGBANK | ||
| Eliminate Route | 80.8 | % | 80.8 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 9.5 | % | 9.5 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 62.2 | % | 62.2 | % | Urinary excretion; Unchanged drug; | DRUGBANK | Eliminate Route | 0.86 | % | 0.86 | % | Faeces excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 96.1 | % | 96.1 | % | DRUGBANK | Protein Binding | 91.9 | % | 91.9 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 1.25 | mg/day | 1.25 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for children | 5.0 | mg/day | 5 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for children | 2.5 | mg/day | 2.5 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for children | 1.25 | mg/day | 1.25 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for children | 1.25 | mg/day | 1.25 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for children | 0.125 | mg/dose | 0.125 | mg/dose | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for adolescents | 5.0 | mg/day | 5 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for adults | 5.0 | mg/day | 5 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
| Max dose for geriatric | 5.0 | mg/day | 5 | mg/day | PO, oral | Children's Xyzal Allergy | (levocetirizine dihydrochloride) | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1