Basic Information
| Drug ID | DDPD06274 |
|
| Drug Name | Alvimopan | |
| Molecular Weight | 424.5326 | |
| Molecular Formula | C25H32N2O4 | |
| CAS Number | 156053-89-3 | |
| SMILES | C[C@H]1CN(C[C@H](CC2=CC=CC=C2)C(=O)NCC(O)=O)CC[C@@]1(C)C1=CC(O)=CC=C1 | |
| External Links | ||
| DRUGBANK | DB06274 | |
| PubChem Compound | 5488548 | |
| PDR | 39 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Water Solubility | 100.0 | mg/L | <0.1 | mg/ml | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 7.0 | % | <7 | % | PO, oral; | DRUGBANK |
| Clearance | 24.1 | L/h | 402±89 | ml/min | DRUGBANK | Clearance | 0.35 | L/h/kg | 5.84 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 30.0 | L | 30±10 | L | DRUGBANK | Volume of Distribution | 0.43 | L/kg | 0.43 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 13.5 | h | 10-17 | h | DRUGBANK | Half-life | 14.0 | h | 10-18 | h | Bile metabolism; | DRUGBANK | Half-life | 5.3 | h | 5.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 35.0 | % | 35 | % | Urinary excretion; Faeces excretion; | DRUGBANK |
| Protein Binding | 85.0 | % | 80-90 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 24.0 | mg/day | 24 | mg/day | PO, oral | Entereg | alvimopan | PDR |
| Max dose for adults | 12.0 | mg | 12 | mg | PO, oral | Entereg | alvimopan | PDR |
| Max dose for elderly | 24.0 | mg/day | 24 | mg/day | PO, oral | Entereg | alvimopan | PDR |
| Max dose for elderly | 12.0 | mg | 12 | mg | PO, oral | Entereg | alvimopan | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1