Basic Information
| Drug ID | DDPD06237 |
|
| Drug Name | Avanafil | |
| Molecular Weight | 483.951 | |
| Molecular Formula | C23H26ClN7O3 | |
| CAS Number | 330784-47-9 | |
| SMILES | COC1=C(Cl)C=C(CNC2=C(C=NC(=N2)N2CCC[C@H]2CO)C(=O)NCC2=NC=CC=N2)C=C1 | |
| External Links | ||
| DRUGBANK | DB06237 | |
| PubChem Compound | 9869929 | |
| PDR | 2389 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 0.63 | h | 30-45 | min | DRUGBANK | |
| Half-life | 8.0 | h | 5.36-10.66 | h | elimination half-life; | DRUGBANK |
| Eliminate Route | 62.0 | % | ~62 | % | Faeces excretion; PO, oral; | DRUGBANK | Eliminate Route | 21.0 | % | ~21 | % | Urinary excretion; PO, oral; | DRUGBANK |
| Protein Binding | 99.0 | % | 99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Stendra | avanafil | PDR |
| Max dose for adults | 50.0 | mg/day | 50 | mg/day | PO, oral | Stendra | avanafil | PDR |
| Max dose for geriatric | 200.0 | mg/day | 200 | mg/day | PO, oral | Stendra | avanafil | PDR |
| Max dose for geriatric | 50.0 | mg/day | 50 | mg/day | PO, oral | Stendra | avanafil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1