Basic Information

Drug ID DDPD06228 ...
Drug Name Rivaroxaban
Molecular Weight 435.881
Molecular Formula C19H18ClN3O5S
CAS Number 366789-02-8
SMILES [H][C@]1(CNC(=O)C2=CC=C(Cl)S2)CN(C(=O)O1)C1=CC=C(C=C1)N1CCOCC1=O
External Links
DRUGBANK DB06228
PubChem Compound 9875401
PDR 278
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 80.0 % >80 % PO, oral; DRUGBANK
T Max 3.0 h 2-4 h PO, oral; DRUGBANK
Clearance 10.0 L/h 10.0 L/h Total clearance; DRUGBANK
Clearance 3.5 L/h ~3.0-4 L/h Renal clearance; DRUGBANK
Clearance 0.14 L/h/kg 2.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 50.0 L 50.0 L Steady state volume of distribution; DRUGBANK
Volume of Distribution 0.70 L/kg 0.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 7.0 h 5-9 h terminal half-life; adults; DRUGBANK
Half-life 12.0 h 11-13 h terminal half-life; Elderly; DRUGBANK
Half-life 7.0 h 7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 66.7 % ~66.7 % Urinary excretion; DRUGBANK
Eliminate Route 33.3 % ~33.3 % Faeces excretion; DRUGBANK
Eliminate Route 23.8 % 23.76 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 2.3 % 2.3 % Faeces excretion; Unchanged drug; DRUGBANK
Protein Binding 93.5 % 92-95 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 30.0 mg/day 30 mg/day PO, oral Xarelto rivaroxaban PDR
Max dose for geriatric 30.0 mg/day 30 mg/day PO, oral Xarelto rivaroxaban PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1