Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.728 | - | 0.728 | - | ACD/Labs |
| Boiling Point | 536.447 | ℃ | 536.447 | ℃ | ACD/Labs |
| Melting Point | 140.0 | ℃ | 140-146 | ℃ | http://www.ema.europa.eu/docs/en_GB/document_library/Application_withdrawal_assessment_report/2010/01/WC500064326.pdf |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 100.0 | % | ~100 | % | PO, oral; food; | food → ; | DRUGBANK |
| T Max | 2.5 | h | 1-4 | h | PO, oral; food; | food → ; | DRUGBANK |
| Clearance | 0.0342 | L/h/kg | 0.57 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Volume of Distribution | 0.60 | L/kg | ~0.6 | L/kg | DRUGBANK | Volume of Distribution | 0.58 | L/kg | 0.58 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 13.0 | h | 13 | h | DRUGBANK | Half-life | 12.3 | h | 12.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 15.0 | % | <15 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 400.0 | mg/day | 400 | mg/day | PO, oral | Vimpat | lacosamide | PDR |
| Max dose for children | 8.0 | mg/kg/day | 8 | mg/kg/day | PO, oral | Vimpat | lacosamide | PDR |
| Max dose for children | 12.0 | mg/kg/day | 12 | mg/kg/day | PO, oral | Vimpat | lacosamide | PDR |
| Max dose for adolescents | 400.0 | mg/day | 400 | mg/day | PO, oral;intravenous injection, IV; | Vimpat | lacosamide | PDR |
| Max dose for adolescents | 400.0 | mg/day | 400 | mg/day | PO, oral | Vimpat | lacosamide | PDR |
| Max dose for adolescents | 8.0 | mg/kg/day | 8 | mg/kg/day | PO, oral | Vimpat | lacosamide | PDR |
| Max dose for adolescents | 12.0 | mg/kg/day | 12 | mg/kg/day | PO, oral | Vimpat | lacosamide | PDR |
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | PO, oral;intravenous injection, IV; | Vimpat | lacosamide | PDR |
| Max dose for geriatric | 400.0 | mg/day | 400 | mg/day | PO, oral;intravenous injection, IV; | Vimpat | lacosamide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1