Basic Information
| Drug ID | DDPD06211 |
|
| Drug Name | Doripenem | |
| Molecular Weight | 420.504 | |
| Molecular Formula | C15H24N4O6S2 | |
| CAS Number | 148016-81-3 | |
| SMILES | [H][C@]12[C@@H](C)C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O | |
| External Links | ||
| DRUGBANK | DB06211 | |
| PubChem Compound | 73303 | |
| PDR | 2118 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 10.3 | L/h | 10.3 | L/h | DRUGBANK | Clearance | 0.20 | L/h/kg | 3.26 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 16.8 | L | 16.8(8.09-55.5） | L | Average volume of distribution; at steady state; normal,healthy; | DRUGBANK | Volume of Distribution | 0.23 | L/kg | 0.23 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.0 | h | 1 | h | normal,healthy; | DRUGBANK | Half-life | 1.2 | h | 1.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 1.0 | % | <1 | % | Faeces excretion; Single dose; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 71.0 | % | 71 | % | Urinary excretion; adults; normal,healthy; Unchanged drug; | DRUGBANK |
| Protein Binding | 8.1 | % | 8.1 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 500.0 | mg | 500 | mg | intravenous injection, IV | q8h | Doribax | doripenem | PDR |
| Max dose for elderly | 500.0 | mg | 500 | mg | intravenous injection, IV | q8h | Doribax | doripenem | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1