Basic Information
| Drug ID | DDPD06210 |
|
| Drug Name | Eltrombopag | |
| Molecular Weight | 442.4666 | |
| Molecular Formula | C25H22N4O4 | |
| CAS Number | 496775-61-2 | |
| SMILES | CC1=NN(C(=O)\C1=N/NC1=CC=CC(C2=CC=CC(=C2)C(O)=O)=C1O)C1=CC=C(C)C(C)=C1 | |
| External Links | ||
| DRUGBANK | DB06210 | |
| PubChem Compound | 9846180 | |
| PDR | 218 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 52.0 | % | >52 | % | PO, oral; | DRUGBANK |
| Half-life | 26.5 | h | ~21-32 | h | normal,healthy; patients; | DRUGBANK | Half-life | 30.5 | h | ~26-35 | h | idiopathic thrombocytopenic purpura; patients; | DRUGBANK |
| Eliminate Route | 59.0 | % | 59 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 31.0 | % | 31 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for children | 150.0 | mg/day | 150 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for children | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for children | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for children | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for children | 2.5 | mg/kg/day | 2.5 | mg/kg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for children | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for adolescents | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for adolescents | 150.0 | mg/day | 150 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for adults | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for adults | 150.0 | mg/day | 150 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for geriatric | 75.0 | mg/day | 75 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
| Max dose for geriatric | 150.0 | mg/day | 150 | mg/day | PO, oral | Promacta | eltrombopag | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1