Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD06204 ...
Drug Name Tapentadol
Molecular Weight 221.3385
Molecular Formula C14H23NO
CAS Number 175591-23-8
SMILES CC[C@H]([C@@H](C)CN(C)C)C1=CC(O)=CC=C1
External Links
DRUGBANK DB06204
PubChem Compound 9838022
PDR 272
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.87 - 2.87 - FDA label
pKa 9.895 - 9.34-10.45 - FDA label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 32.0 % 32 % PO, oral; immediate release formulation; DRUGBANK
Bioavailability 32.0 % 32 % PO, oral; extended release formulation; DRUGBANK
C Max 64.2 ng/ml 64.2 ng/ml PO, oral; immediate release formulation; DRUGBANK
C Max 22.5 ng/ml 22.5 ng/ml PO, oral; extended release formulation; DRUGBANK
T Max 1.5 h 1.5 h PO, oral; immediate release formulation; DRUGBANK
T Max 5.0 h 5.0 h PO, oral; extended release formulation; DRUGBANK
Metabolic 97.0 % 97 % Inactive metabolite; DRUGBANK
Clearance 91.8 L/h 1530 ± 177 ml/min Total clearance; DRUGBANK
Clearance 1.3 L/h/kg 21.33 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 540.0 L 540±98 L intravenous injection, IV; DRUGBANK
Volume of Distribution 4.6 L/kg 4.64 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 4.0 h 4 h elimination half-life; intravenous injection, IV; DRUGBANK
Half-life 2.4 h 2.39 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 3200.0 mg/kg 3200.0 mg/kg PO, oral; rabbit; DRUGBANK
Toxicity LD50 300.0 mg/kg 300.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 980.0 mg/kg 980.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 99.0 % 99 % Urinary excretion; DRUGBANK
Eliminate Route 3.0 % 3 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 20.0 % ~20 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 500.0 mg/day 500 mg/day PO, oral Nucynta tapentadol PDR
Max dose for adults 700.0 mg/day 700 mg/day PO, oral Nucynta tapentadol PDR
Max dose for geriatric 500.0 mg/day 500 mg/day PO, oral Nucynta tapentadol PDR
Max dose for geriatric 700.0 mg/day 700 mg/day PO, oral Nucynta tapentadol PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1