Basic Information
| Drug ID | DDPD06203 |
|
| Drug Name | Alogliptin | |
| Molecular Weight | 339.3916 | |
| Molecular Formula | C18H21N5O2 | |
| CAS Number | 850649-61-5 | |
| SMILES | CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O | |
| External Links | ||
| DRUGBANK | DB06203 | |
| PubChem Compound | 11450633 | |
| PDR | 3076 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 100.0 | % | 100 | % | PO, oral; food; | food → ; | DRUGBANK |
| T Max | 1.5 | h | 1-2 | h | PO, oral; normal,healthy; diabetes; | DRUGBANK | |
| Metabolic | 15.0 | % | 10-20 | % | Liver metabolism; | DRUGBANK | |
| Clearance | 9.6 | L/h | 9.6 | L/h | Plasma clearance; | DRUGBANK | Clearance | 14.0 | L/h | 14.0 | L/h | Total clearance; | DRUGBANK |
| Volume of Distribution | 417.0 | L | 417.0 | L | intravenous infusion, IV in drop; normal,healthy; | DRUGBANK | |
| Half-life | 21.0 | h | 21 | h | terminal half-life; | DRUGBANK | |
| Eliminate Route | 76.0 | % | 76 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 13.0 | % | 13 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 65.5 | % | 60-71 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 20.0 | % | 20 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 25.0 | mg/day | 25 | mg/day | PO, oral | Nesina | alogliptin | PDR |
| Max dose for geriatric | 25.0 | mg/day | 25 | mg/day | PO, oral | Nesina | alogliptin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1