Basic Information
| Drug ID | DDPD06176 |
|
| Drug Name | Romidepsin | |
| Molecular Weight | 540.69 | |
| Molecular Formula | C24H36N4O6S2 | |
| CAS Number | 128517-07-7 | |
| SMILES | C\C=C1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C | |
| External Links | ||
| DRUGBANK | DB06176 | |
| PubChem Compound | 57515973 | |
| PDR | 2922 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 8.4 | L/h | 8.4 | L/h | DRUGBANK | Clearance | 0.44 | L/h/kg | 7.4 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 44.5 | L | 44.5 | L | DRUGBANK | Volume of Distribution | 1.2 | L/kg | 1.2 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.0 | h | ~3 | h | DRUGBANK | Half-life | 11.0 | h | 11 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 93.0 | % | 92-94 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 14.0 | mg/m2 | 14 | mg/m2 | intravenous injection, IV | Istodax | romidepsin | PDR |
| Max dose for geriatric | 14.0 | mg/m2 | 14 | mg/m2 | intravenous injection, IV | Istodax | romidepsin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1