Basic Information
| Drug ID | DDPD06151 |
|
| Drug Name | Acetylcysteine | |
| Molecular Weight | 163.195 | |
| Molecular Formula | C5H9NO3S | |
| CAS Number | 616-91-1 | |
| SMILES | CC(=O)N[C@@H](CS)C(O)=O | |
| External Links | ||
| DRUGBANK | DB06151 | |
| PubChem Compound | 12035 | |
| PDR | 129 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 109.5 | ℃ | 109-110 | ℃ | Martin, T.A. and Waller, C.W.; US. Patent 3,184,505; May 18, 1965; assigned to Mead Johnson & Company. |
| pKa | 9.52 | - | 9.52 | - | SERJEANT & DEMPSEY (1979) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 8.0 | % | 6-10 | % | PO, oral; | DRUGBANK | Bioavailability | 3.0 | % | <3 | % | skin/dermal; | DRUGBANK |
| Clearance | 0.19 | L/h/kg | 3.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.55 | L/kg | 0.55 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.6 | h | 5.6 | h | adults; | DRUGBANK | Half-life | 11.0 | h | 11 | h | Neonates; | DRUGBANK | Half-life | 5.5 | h | 5.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity Lethal Dose | 1000.0 | mg/kg | 1000.0 | mg/kg | mouse; | DRUGBANK | Toxicity Lethal Dose | 2445.0 | mg/kg | 2445.0 | mg/kg | Rattus, Rat; | DRUGBANK | Toxicity Lethal Dose | 1500.0 | mg/kg | 1500.0 | mg/kg | guinea pigs; | DRUGBANK | Toxicity Lethal Dose | 1200.0 | mg/kg | 1200.0 | mg/kg | rabbit; | DRUGBANK | Toxicity Lethal Dose | 500.0 | mg/kg | 500.0 | mg/kg | dog; | DRUGBANK |
| Protein Binding | 83.0 | % | 83 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 150.0 | mg/kg | 150 | mg/kg | intravenous injection, IV | Acetadote | acetylcysteine | PDR |
| Max dose for adults | 1500.0 | mg | 1500 | mg | intravenous injection, IV | Acetadote | acetylcysteine | PDR |
| Max dose for adults | 50.0 | mg/kg | 50 | mg/kg | intravenous injection, IV | Acetadote | acetylcysteine | PDR |
| Max dose for adults | 5000.0 | mg | 5000 | mg | intravenous injection, IV | Acetadote | acetylcysteine | PDR |
| Max dose for adults | 100.0 | mg/kg | 100 | mg/kg | intravenous injection, IV | Acetadote | acetylcysteine | PDR |
| Max dose for adults | 10000.0 | mg | 10000 | mg | intravenous injection, IV | Acetadote | acetylcysteine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1