DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD06077
Drug Name	Lumateperone
Molecular Weight	393.506
Molecular Formula	C24H28FN3O
CAS Number	313368-91-1
SMILES	[H][C@]12CCN(CCCC(=O)C3=CC=C(F)C=C3)C[C@@]1([H])C1=CC=CC3=C1N2CCN3C
External Links
	DRUGBANK	DB06077
	PubChem Compound	21302490

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	2.328	-	2.328	-	http://www.chemspider.com/Chemical-Structure.19328801.html

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
T Max	3.5	h	3-4	h	PO, oral;	DRUGBANK
Clearance	27.9	L/h	27.9	L/h		DRUGBANK
Volume of Distribution	4.1	L/kg	4.1	L/kg	intravenous injection, IV;	DRUGBANK
Half-life	15.5	h	13-18	h		DRUGBANK
Half-life	20.0	h	20	h	Metabolite;	DRUGBANK
Half-life	21.0	h	21	h	Metabolite;	DRUGBANK
Eliminate Route	58.0	%	~58	%	Urinary excretion;	DRUGBANK
Eliminate Route	29.0	%	~29	%	Faeces excretion;	DRUGBANK
Protein Binding	97.4	%	~97.4	%	plasma proteins;	DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1