Basic Information
| Drug ID | DDPD05521 |
|
| Drug Name | Telaprevir | |
| Molecular Weight | 679.8493 | |
| Molecular Formula | C36H53N7O6 | |
| CAS Number | 402957-28-2 | |
| SMILES | [H][C@@]12CCC[C@]1([H])[C@H](N(C2)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C1=NC=CN=C1)C1CCCCC1)C(C)(C)C)C(=O)N[C@@H](CCC)C(=O)C(=O)NC1CC1 | |
| External Links | ||
| DRUGBANK | DB05521 | |
| PubChem Compound | 3010818 | |
| PDR | 599 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Water Solubility | 4.7 | mg/L | 0.0047 | mg/ml | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 4.5 | h | 4-5 | h | PO, oral; | DRUGBANK |
| Clearance | 32.4 | L/h | 32.4 | L/h | Total clearance; | DRUGBANK |
| Volume of Distribution | 252.0 | L | 252.0 | L | DRUGBANK | |
| Half-life | 4.4 | h | 4.0-4.7 | h | Single dose; | DRUGBANK | Half-life | 10.0 | h | 9-11 | h | effective half-life; at steady state; | DRUGBANK |
| Eliminate Route | 82.0 | % | 82 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 9.0 | % | 9 | % | lung excretion; | DRUGBANK | Eliminate Route | 1.0 | % | 1 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 67.5 | % | 59-76 | % | plasma proteins; Single dose; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 2250.0 | mg/day | 2250 | mg/day | PO, oral | Incivek | telaprevir | PDR |
| Max dose for geriatric | 2250.0 | mg/day | 2250 | mg/day | PO, oral | Incivek | telaprevir | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1