Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.38 | - | 2.38 | - | MSDS |
| Melting Point | 140.0 | ℃ | 140 | ℃ | MSDS |
| Water Solubility | 210.0 | mg/L | 0.21 | mg/ml | MSDS |
| pKa | 8.87 | - | 8.87 | - | MSDS |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 3275.0 | ng.h/ml | 3275.0 | ng.h/ml | PO, oral; | DRUGBANK |
| C Max | 688.0 | ng/ml | 688 | ng/ml | PO, oral; | DRUGBANK |
| T Max | 4.0 | h | 4(1-6) | h | PO, oral; | DRUGBANK |
| Clearance | 11.5 | L/h | 11.4-11.6 | L/h | apparent clearance; normal,healthy; | DRUGBANK |
| Volume of Distribution | 40.3 | L | 40.3 | L | Steady state volume of distribution; Multiple dose; gastroesophageal reflux disease; patients; | DRUGBANK |
| Half-life | 1.5 | h | ~1-2 | h | normal,healthy; | DRUGBANK | Half-life | 1.5 | h | ~1-2 | h | gastroesophageal reflux disease; patients; | DRUGBANK |
| Toxicity LD50 | 5000.0 | mg/kg | >5000 | mg/kg | PO, oral; mouse; Rattus, Rat; dog; | DRUGBANK |
| Eliminate Route | 50.7 | % | 50.7 | % | Faeces excretion; PO, oral; | DRUGBANK | Eliminate Route | 47.6 | % | 47.6 | % | Urinary excretion; PO, oral; | DRUGBANK |
| Protein Binding | 97.5 | % | 96-99 | % | plasma proteins; normal,healthy; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 60.0 | mg/day | 60 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
| Max dose for children | 30.0 | mg/day | 30 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
| Max dose for adolescents | 60.0 | mg/day | 60 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
| Max dose for adolescents | 30.0 | mg/day | 30 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
| Max dose for adults | 60.0 | mg/day | 60 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
| Max dose for adults | 30.0 | mg/day | 30 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
| Max dose for geriatric | 60.0 | mg/day | 60 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
| Max dose for geriatric | 30.0 | mg/day | 30 | mg/day | PO, oral | Dexilant | dexlansoprazole | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1