Basic Information

Drug ID DDPD05239 ...
Drug Name Cobimetinib
Molecular Weight 531.318
Molecular Formula C21H21F3IN3O2
CAS Number 934660-93-2
SMILES OC1(CN(C1)C(=O)C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)[C@@H]1CCCCN1
External Links
DRUGBANK DB05239
PubChem Compound 16222096
PDR 3832
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 46.0 % 46 % DRUGBANK
Clearance 13.9 L/h 13.9 L/h DRUGBANK
Clearance 0.17 L/h/kg 2.8 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 806.0 L 806.0 L tumor; patients; DRUGBANK
Volume of Distribution 15.4 L/kg 15.4 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 44.0 h 44 h DRUGBANK
Half-life 68.8 h 68.8 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 76.0 % 76 % Faeces excretion; DRUGBANK
Eliminate Route 17.8 % 17.8 % Urinary excretion; DRUGBANK
Eliminate Route 6.6 % 6.6 % Faeces excretion; Unchanged drug; DRUGBANK
Eliminate Route 1.6 % 1.6 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 95.0 % 95 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 60.0 mg/day 60 mg/day PO, oral q4w Cotellic cobimetinib PDR
Max dose for geriatric 60.0 mg/day 60 mg/day PO, oral q4w Cotellic cobimetinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1