Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | 27.6 | - | 27.6 | - | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139342/ |
| Log P | 2.75 | - | 2.75 | - | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139342/ |
| Boiling Point | 462.3 | ℃ | 462.3±55.0 | ℃ | http://www.chemspider.com/Chemical-Structure.401693.html |
| Water Solubility | 1000.0 | mg/L | <1 | mg/ml | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139342/ |
| pKa | 7.0 | - | 7 | - | https://www.researchgate.net/publication/310833979_Simultaneous_HPLC_assay_for_pretomanid_PA-824_moxifloxacin_and_pyrazinamide_in_an_inhaler_formulation_for_drug-resistant_tuberculosis |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 28100.0 | ng.h/ml | 28.1 | ug.h/ml | PO, oral; fasting; | DRUGBANK | AUC | 51600.0 | ng.h/ml | 51.6 | ug.h/ml | PO, oral; food; | DRUGBANK |
| C Max | 1700.0 | ng/ml | 1.7 | ug/ml | Oral single dose; | DRUGBANK | C Max | 1100.0 | ng/ml | 1.1 | ug/ml | Oral single dose; different study; | DRUGBANK |
| T Max | 4.5 | h | 4-5 | h | PO, oral; food; fasting; | DRUGBANK |
| Metabolic | 20.0 | % | 20 | % | DRUGBANK | |
| Clearance | 4.8 | L/h | 4.8±0.2 | L/h | DRUGBANK | Clearance | 7.6 | L/h | 7.6 | L/h | Oral single dose; fasting; | DRUGBANK | Clearance | 3.9 | L/h | 3.9 | L/h | Oral single dose; food; | DRUGBANK |
| Volume of Distribution | 130.0 | L | 130±5 | L | DRUGBANK | Volume of Distribution | 180.0 | L | 180±51.3 | L | normal,healthy; fasting; | DRUGBANK | Volume of Distribution | 97.0 | L | 97.0±17.2 | L | normal,healthy; food; | DRUGBANK |
| Half-life | 17.2 | h | 16.9-17.4 | h | elimination half-life; normal,healthy; | DRUGBANK | Half-life | 18.0 | h | 18 | h | DRUGBANK |
| Eliminate Route | 53.0 | % | ~53 | % | Urinary excretion; PO, oral; Male, men; adults; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 1.0 | % | ~1 | % | Urinary excretion; PO, oral; Male, men; adults; normal,healthy; human, homo sapiens; Unchanged drug; | DRUGBANK |
| Protein Binding | 86.4 | % | 86.4 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1