Basic Information
| Drug ID | DDPD05109 |
|
| Drug Name | Trabectedin | |
| Molecular Weight | 761.837 | |
| Molecular Formula | C39H43N3O11S | |
| CAS Number | 114899-77-3 | |
| SMILES | [H][C@@]12[C@@H]3SC[C@]4(NCCC5=C4C=C(OC)C(O)=C5)C(=O)OC[C@H](N1[C@@H](O)[C@@H]1CC4=CC(C)=C(OC)C(O)=C4[C@H]2N1C)C1=C2OCOC2=C(C)C(OC(C)=O)=C31 | |
| External Links | ||
| DRUGBANK | DB05109 | |
| PubChem Compound | 108150 | |
| PDR | 3815 | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.72 | L/h/kg | 12 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 25.0 | L/kg | 25 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 41.5 | h | 33-50 | h | DRUGBANK | Half-life | 44.0 | h | 44 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 96.0 | % | 94-98 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1.5 | mg/m2 | 1.5 | mg/m2 | intravenous injection, IV | q3w | Yondelis | trabectedin | PDR |
| Max dose for geriatric | 1.5 | mg/m2 | 1.5 | mg/m2 | intravenous injection, IV | q3w | Yondelis | trabectedin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1