| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Reference |
| Bioavailability |
44.0 |
% |
43-45 |
% |
inhalation, IH; |
DRUGBANK |
| T Max |
0.25 |
h |
15 |
min |
inhalation, IH; |
DRUGBANK |
| Clearance |
0.83 |
L/h |
0.46-1.2 |
L/h |
Renal clearance; |
DRUGBANK |
Clearance |
21.1 |
L/h |
18.8-23.3 |
L/h |
Plasma clearance; |
DRUGBANK |
Clearance |
0.27 |
L/h/kg |
4.48 |
ml/min/kg |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution |
2459.0 |
L |
2361-2557 |
L |
intravenous infusion, IV in drop; |
DRUGBANK |
Volume of Distribution |
19.4 |
L/kg |
19.4 |
L/kg |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Half-life |
85.8 |
h |
45.5-126 |
h |
|
DRUGBANK |
Half-life |
48.0 |
h |
40-56 |
h |
effective half-life; Multiple dose; |
DRUGBANK |
Half-life |
324.0 |
h |
12-15 |
day |
at steady state; |
DRUGBANK |
Half-life |
92.5 |
h |
92.5 |
h |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route |
54.0 |
% |
54 |
% |
Faeces excretion; PO, oral; human, homo sapiens; Unchanged drug; |
DRUGBANK |
| Protein Binding |
94.7 |
% |
94.1-95.3 |
% |
high protein binding; human, homo sapiens; |
DRUGBANK |
Protein Binding |
95.7 |
% |
95.1-96.2 |
% |
plasma proteins; high protein binding; human, homo sapiens; |
DRUGBANK |
