Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Water Solubility | 140.0 | mg/L | 0.14 | mg/ml | FDA Label |
| pKa | 7.87 | - | 7.87,8.71 | - | FDA LABEL | pKa | 8.71 | - | 7.87,8.71 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 74.4 | L/h | 1240.0 | ml/min | DRUGBANK | Clearance | 1.4 | L/h/kg | 23.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 409.0 | L | 409±76.7 | L | DRUGBANK | Volume of Distribution | 0.80 | L/kg | 0.8 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.1 | h | 1.1 | h | elimination half-life; | DRUGBANK | Half-life | 1.6 | h | 1.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 2.0 | % | <2 | % | Unchanged drug; | DRUGBANK |
| Protein Binding | 92.9 | % | 92.9 | % | DRUGBANK | Protein Binding | 95.8 | % | 95.8 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1000.0 | mg/m2/day | 1000 | mg/m2/day | intravenous injection, IV | Beleodaq | belinostat | PDR |
| Max dose for geriatric | 1000.0 | mg/m2/day | 1000 | mg/m2/day | intravenous injection, IV | Beleodaq | belinostat | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1