Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD04948 ...
Drug Name Lofexidine
Molecular Weight 259.132
Molecular Formula C11H12Cl2N2O
CAS Number 31036-80-3
SMILES CC(OC1=C(Cl)C=CC=C1Cl)C1=NCCN1
External Links
DRUGBANK DB04948
PubChem Compound 30668

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 5.37 - 5.37 - FDA Advisory Committee Briefing Document.
Boiling Point 421.5 ℃ 421.5 ℃ 'MSDS'
Melting Point 222.0 ℃ 221-223 ℃ U.S. Patent 3,966,757.
pKa 9.43 - 9.43 - FDA Advisory Committee Briefing Document.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 72.0 % >72 % PO, oral; DRUGBANK
C Max 1.3 ng/ml 1.26 ng/ml PO, oral; DRUGBANK
T Max 3.5 h 2-5 h PO, oral; DRUGBANK
T Max 3.0 h 3 h PO, oral; DRUGBANK
Clearance 17.6 L/h 17.6 L/h Total clearance; intravenous injection, IV; DRUGBANK
Volume of Distribution 300.0 L 300.0 L DRUGBANK
Half-life 11.0 h 11 h elimination half-life; DRUGBANK
Eliminate Route 94.0 % 94 % Urinary excretion; DRUGBANK
Eliminate Route 0.93 % 0.93 % Faeces excretion; DRUGBANK
Protein Binding 55.0 % ~55 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1