Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD04920 ...
Drug Name Clevidipine
Molecular Weight 456.316
Molecular Formula C21H23Cl2NO6
CAS Number 167221-71-8
SMILES CCCC(=O)OCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(Cl)=C1Cl)C(=O)OC
External Links
DRUGBANK DB04920
PubChem Compound 153994
PDR 2122

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 8.5 L/h/kg 142 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.58 L/kg 0.58 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.0167 h 1 min DRUGBANK
Half-life 0.30 h 0.3 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 68.5 % 63-74 % Urinary excretion; DRUGBANK
Eliminate Route 14.5 % 7-22 % Faeces excretion; DRUGBANK
Protein Binding 99.5 % >99.5 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 768.0 mg/day 32 mg/h intravenous injection, IV Cleviprex clevidipine PDR
Max dose for adults 1000.0 mg/day 1000 mg/day intravenous injection, IV Cleviprex clevidipine PDR
Max dose for adults 504.0 mg/day 21 mg/h intravenous injection, IV Cleviprex clevidipine PDR
Max dose for elderly 32.0 mg/hr 32 mg/hr intravenous injection, IV Cleviprex clevidipine PDR
Max dose for elderly 1000.0 mg/day 1000 mg/day intravenous injection, IV Cleviprex clevidipine PDR
Max dose for elderly 21.0 mg/hr 21 mg/hr intravenous injection, IV Cleviprex clevidipine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1