Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD04896 ...
Drug Name Milnacipran
Molecular Weight 246.354
Molecular Formula C15H22N2O
CAS Number 92623-85-3
SMILES CCN(CC)C(=O)C1(CC1CN)C1=CC=CC=C1
External Links
DRUGBANK DB04896
PubChem Compound 65833
PDR 2094
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 179.0 ℃ 179 ℃ Bernstein CD, Albrecht KL, Marcus DA: Milnacipran for fibromyalgia: a useful addition to the treatment armamentarium. Expert Opin Pharmacother. 2013 Mar 19. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23506481
Water Solubility 19000.0 mg/L 19 mg/ml MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 5196.0 ng.h/ml 5196.0 ng.h/ml PO, oral; Raceme L; DRUGBANK
Bioavailability 87.5 % 85-90 % PO, oral; DRUGBANK
Bioavailability 92.0 % 92 % PO, oral; Raceme L; DRUGBANK
C Max 341.0 ng/ml 341 ng/ml PO, oral; Raceme L; DRUGBANK
T Max 3.0 h 2-4 h PO, oral; Raceme D/L; DRUGBANK
T Max 7.0 h 6-8 h PO, oral; Raceme L; DRUGBANK
Tss 42.0 h 36-48 h PO, oral; Raceme D/L; DRUGBANK
Clearance 40.0 L/h ~40 L/h Plasma clearance; DRUGBANK
Clearance 0.49 L/h/kg 8.17 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 430.0 L 387-473 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 400.0 L 400.0 L Average volume of distribution; intravenous injection, IV; Single dose; normal,healthy; DRUGBANK
Volume of Distribution 4.5 L/kg 4.51 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 7.0 h ~6-8 h elimination half-life; Raceme D/L; DRUGBANK
Half-life 9.0 h 8-10 h elimination half-life; Raceme D; DRUGBANK
Half-life 5.0 h 4-6 h elimination half-life; DRUGBANK
Half-life 12.0 h ~12 h elimination half-life; DRUGBANK
Half-life 6.5 h 6.48 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 213.0 mg/kg 213.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity NOAEL 100.0 mg/kg/day 100.0 mg/kg/day Rattus, Rat; rabbit; DRUGBANK
Eliminate Route 58.0 % ~58 % Urinary excretion; Liquid; Unchanged drug; DRUGBANK
Protein Binding 13.0 % 13 % Raceme D/L; DRUGBANK
Protein Binding 22.0 % 22 % plasma proteins; Raceme L; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 100.0 mg/day 100 mg/day PO, oral Savella milnacipran hydrochloride PDR
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Savella milnacipran hydrochloride PDR
Max dose for geriatric 200.0 mg/day 200 mg/day PO, oral Savella milnacipran hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1