Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD04861 ...
Drug Name Nebivolol
Molecular Weight 405.435
Molecular Formula C22H25F2NO4
CAS Number 118457-14-0
SMILES OC(CNCC(O)C1CCC2=C(O1)C=CC(F)=C2)C1CCC2=C(O1)C=CC(F)=C2
External Links
DRUGBANK DB04861
PubChem Compound 71301
PDR 156
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.183 - 4.183 - https://www.sigmaaldrich.com/MSDS/MSDS/DisplayMSDSPage.do?country=CA&language=en&productNumber=N1915&brand=SIGMA&PageToGoToURL=https%3A%2F%2Fwww.sigmaaldrich.com%2Fcatalog%2Fproduct%2Fsigma%2Fn1915%3Flang%3Den
Melting Point 225.5 ℃ 223.0-228.0 ℃ https://www.tcichemicals.com/eshop/en/gb/commodity/N0954/
Water Solubility 910.0 mg/L 0.091 g/100ml http://www.medicines.org.au/files/txpnebiv.pdf
pKa 8.13 - 8.13 - http://www.medicines.org.au/files/txpnebiv.pdf

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 13.8 ng.h/ml 13.78±15.27 ng.h/ml Raceme D; DRUGBANK
AUC 27.7 ng.h/ml 27.72±15.32 ng.h/ml Raceme L; DRUGBANK
AUC 41.5 ng.h/ml 41.50±29.76 ng.h/ml Raceme D/L; DRUGBANK
AUC 396.8 ng.h/ml 396.78±297.94 ng.h/ml Derivative; DRUGBANK
Bioavailability 54.0 % 12-96 % PO, oral; poor metabolizers, PM; extensive metabolizers, EM; DRUGBANK
C Max 2.8 ng/ml 2.75±1.55 ng/ml Raceme D; DRUGBANK
C Max 5.3 ng/ml 5.29±2.06 ng/ml Raceme L; DRUGBANK
C Max 8.0 ng/ml 8.02±3.47 ng/ml Raceme D/L; DRUGBANK
C Max 68.3 ng/ml 68.34±44.68 ng/ml Derivative; DRUGBANK
T Max 2.8 h 1.5-4 h PO, oral; poor metabolizers, PM; extensive metabolizers, EM; DRUGBANK
Clearance 1241.6 L/h 1241.63±749.77 L/h DRUGBANK
Clearance 435.5 L/h 435.53±180.93 L/h DRUGBANK
Clearance 635.3 L/h 635.31±300.25 L/h DRUGBANK
Clearance 0.84 L/h/kg 14 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 10290.8 L 10290.81±3911.72 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 8066.7 L 8066.66±4055.50 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 10423.4 L 10423.42±6796.50 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 11.0 L/kg 11 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 12.0 h 12 h Raceme D; extensive metabolizers, EM; DRUGBANK
Half-life 19.0 h 19 h Raceme D; poor metabolizers, PM; DRUGBANK
Half-life 10.0 h 10 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 38.0 % 38 % Urinary excretion; extensive metabolizers, EM; DRUGBANK
Eliminate Route 44.0 % 44 % Faeces excretion; extensive metabolizers, EM; DRUGBANK
Eliminate Route 67.0 % 67 % Urinary excretion; poor metabolizers, PM; DRUGBANK
Eliminate Route 13.0 % 13 % Faeces excretion; poor metabolizers, PM; DRUGBANK
Protein Binding 98.0 % 98 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Bystolic nebivolol PDR
Max dose for elderly 40.0 mg/day 40 mg/day PO, oral Bystolic nebivolol PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1